ZAP70 Expression Within del6q21, del11q13 and del17p13 Cytogenetic Subgroups of Iranian Patients with Chronic Lymphocytic Leukemia
نویسندگان
چکیده
منابع مشابه
ZAP70 Expression Within del6q21, del11q13 and del17p13 Cytogenetic Subgroups of Iranian Patients with Chronic Lymphocytic Leukemia
BACKGROUND B-cell chronic lymphocytic leukemia (B-CLL) is the most common form of leukemia in adults. Some reports showed that expression of ZAP70 gene and chromosomal abnormality are two prognostic factors in management of B-CLL. OBJECTIVES In this study, we determined ZAP70 mRNA expression level in the del17p13, del6q21 and del11q13 subgroups of Iranian B-CLL patients to investigate prognos...
متن کاملAnalysis of CD38 and ZAP70 mRNA expression among cytogenetic subgroups of Iranian chronic-lymphocytic-leukemia patients.
Chromosomal abnormalities and ZAP70 expression profile are two major independent prognostic markers in B-cell chronic lymphocytic leukemia. We investigated a possible correlation between these two markers. ZAP70 expression using real-time RT-PCR was examined in 20 B-cell chronic lymphocytic leukemia patients with del13q14, 13 patients with del11q22, 15 patients with trisomy 12, and 16 pati...
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background b-cell chronic lymphocytic leukemia (b-cll) is the most common form of leukemia in adults. some reports showed that expression of zap70 gene and chromosomal abnormality are two prognostic factors in management of b-cll objectives in this study, we determined zap70 mrna expression level in the del17p13, del6q21 and del11q13 subgroups of iranian b-cll patients to investigate prognostic...
متن کاملExpression Profiles of miR-93 and miR-330 in Iranian Patients with Chronic Lymphocytic Leukemia
Background and Aims: Chronic lymphocytic leukemia (CLL) is the most common adult human leukemia. MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression. Research has shown that in CLL, microRNAs can have function as oncogenes or tumor suppressors. Some studies demonstrated that the expression of microRNA-93 (miR-93) and microRNA-330 (miR-330) have been changed in several can...
متن کاملFISH Analysis for del6q21 and del17p13 in B-cell Chronic Lymphocytic Leukemia in Iranians
BACKGROUND B-cell chronic lymphocytic leukemia (B-CLL) is the most common leukemia in the Western world. Major progress has been made in assessing typical chromosomal abnormalities and recognition of the correlation of these chromosomal abnormalities with laboratory features and clinical course of the disease. The most frequent genomic changes are deletions at 13q14, 11q22-23 and 17p13 and tris...
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ژورنال
عنوان ژورنال: Iranian Red Crescent Medical Journal
سال: 2014
ISSN: 2074-1804,2074-1812
DOI: 10.5812/ircmj.22528